Volume 2, Issue 1 (Winter 2018)                   Multidiscip Cancer Investig 2018, 2(1): 26-32 | Back to browse issues page

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Atashgar K, Sheikhaliyan A, Tajvidi M, Molana H, Jalaeiyan L. Survival analysis of breast cancer patients with different chronic diseases through parametric and semi-parametric approaches. Multidiscip Cancer Investig. 2018; 2 (1) :26-32
URL: http://mcijournal.com/article-1-69-en.html
Abstract:   (430 Views)

Introduction: There is no evidence in publications on the extent of dependency between chronic diseases and survival rate of breast cancer. The objective of this study is to illustrate through a comprehensive investigation, the effect of chronic diseases such as diabetes, blood pressure and endocrine disorders (i.e., hypo- and hyperthyroidism) in survival analysis of breast cancer.

Methods: we are investigated 1822 breast cancer patients who were referred to three hospitals in Tehran (Capital of Iran) in the period of 2008-2017. A comprehensive study was conducted using the information on the chronic diseases of those patients. Parametric and semiparametric approaches and non-parametric Kaplan-Meier analysis were considered in this study and two models were proposed for the analysis of breast cancer survival

Results: In this study, it was found that chronic diseases (if there are any) should be considered in the survival analysis of breast cancer. It was also determined that among the patients, 436 had a background of chronic diseases including hypertension, diabetes, hypo- and hyperthyroidism and heart problems at frequencies 12.38%, 11.69%, 8.71% and 8.02%, respectively.

Conclusions: It was found out in this comprehensive experiment that there is a significant difference in the survival rate of breast cancer in conditions with and without chronic diseases. Statistical analyses that chronic diseases have an effect on the survival probability of breast cancer (p=0.001), such that heart problems and a combination of chronic diseases have the most influence on the survival rate of breast cancer.

Full-Text [PDF 677 kb]   (66 Downloads)    
Type of Study: Case Report and Series | Subject: diagnosis
Received: 2017/09/2 | Accepted: 2017/12/12 | ePublished: 2017/01/1

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